Macrocycle-Antibiotic Hybrids: A Path to Clinical Candidates

The Path to Clinical Practice

Circulation Research is available at http://circres.ahajournals.org DOI: 10.1161/CIRCRESAHA.113.300269 Abstract: Gene therapy, aimed at the correction of key pathologies being out of reach for conventional drugs, bears the potential to alter the treatment of cardiovascular diseases radically and thereby of heart failure. Heart failure gene therapy refers to a therapeutic system of targeted drug...

University revenue diversification: a path to financial stability

The purpose of present study was to investigate revenue diversification among Iranian public universities in order to improve the stability and flexibility of financial resources. A quantitative practical correlational research design was utilized for this study. The spatial scope of research was one and two level comprehensive public and industrial public universities during 2013-2018. Data we...

GlyT-1 Inhibitors: From Hits to Clinical Candidates

The treatment of schizophrenia has long been dominated by aminergic receptor antagonist-based therapeutics largely founded on the dopamine hypothesis of schizophrenia. More recently the glutamatergic theory has come to the fore which may potentially address some of the deficiencies of current therapies. While there are many approaches to manipulating the glutamatergic system, the most advanced ...

Chemical philanthropy: a path forward for antibiotic discovery?

Changing the volume of a giant macrocycle: the swelling of the macrocycle with organic solvents.

The novel tetrahedral macrocycles 1a-1c have been synthesized. Macrocycles 1a and 1c were revealed to have the property to increase in volume in solution by complexation between the macrocycle and the solvent molecules.